ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate

Base Information

Chemical Name:ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate
CAS No.:1352440-87-9
Molecular Formula:C₂₅H₂₈N₂O₅
Molecular Weight:436.508
Hs Code.:

Synonyms:ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate

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Chemical Property of ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate

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Technology Process of ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate

There total 5 articles about ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 14113-02-1
ethyl 8-chloro-8-oxooctanoate

: 1352440-71-1
C₁₅H₁₂N₂O₂

: 1352440-87-9
ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate

Guidance literature:: With triethylamine; In tetrahydrofuran; for 3h; Cooling with ice;
DOI:10.1016/j.bmc.2012.05.034

Reference yield:

: 1352440-70-0
N-(3-ethynylphenyl)-2-hydroxy-5-nitrobenzamide

: 1352440-87-9
ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: iron; acetic acid / tetrahydrofuran; ethanol / 7 h / Reflux

1.2: pH 10 / Saturated solution

2.1: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

With iron; acetic acid; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2012.05.034

Reference yield:

: 14113-01-0
Ethyl hydrogen suberate

: 1352440-87-9
ethyl 8-(4-hydroxy-3-(N-3-ethynylphenylcarbamoyl)phenylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride

2: triethylamine / tetrahydrofuran / 3 h / Cooling with ice

With thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmc.2012.05.034