1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

Base Information

Chemical Name:1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide
CAS No.:1413061-43-4
Molecular Formula:C₃₃H₃₂FN₇O₄
Molecular Weight:609.66
Hs Code.:

Synonyms:1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

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Chemical Property of 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

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Technology Process of 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

There total 5 articles about 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1413064-86-4
1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carbonitrile

: 1413061-43-4
1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

Guidance literature:: With water; hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In tetrahydrofuran; for 1h; Reflux;

Reference yield:

: 1413064-54-6
5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile

: 1413061-43-4
1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / ethanol / 20 °C

1.2: Cooling with ice

2.1: potassium tert-butylate / dimethyl sulfoxide / 0.08 h / 20 °C

2.2: 20 °C

3.1: sodium hydrogencarbonate / copper(l) iodide / dimethyl sulfoxide / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

4.1: water / hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / tetrahydrofuran / 1 h / Reflux

With hydrogenchloride; potassium tert-butylate; water; sodium hydrogencarbonate; copper(l) iodide; hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In tetrahydrofuran; ethanol; dimethyl sulfoxide;

Reference yield:

: 1413064-58-0
5-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carbonitrile

: 1413061-43-4
1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.08 h / 20 °C

1.2: 20 °C

2.1: sodium hydrogencarbonate / copper(l) iodide / dimethyl sulfoxide / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: water / hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / tetrahydrofuran / 1 h / Reflux

With potassium tert-butylate; water; sodium hydrogencarbonate; copper(l) iodide; hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In tetrahydrofuran; dimethyl sulfoxide;