5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile

Base Information

• Chemical Name: 5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile
• CAS No.: 1413064-54-6
• Molecular Formula: C₂₁H₂₉N₅O₃Si
• Molecular Weight: 427.578
• Mol file: 1413064-54-6.mol

Synonyms:5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile

Chemical Property of 5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile

There total 2 articles about 5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.1%

5-amino-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile (1207176-38-2) + (4-bromophenyl)(morpholino)methanone (127580-92-1) → 5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile (1413064-54-6)

Guidance literature:

With caesium carbonate; In toluene; at 120 ℃; for 5h; Sealed tube; Inert atmosphere;

Reference yield:

(2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile (1413064-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: caesium carbonate / toluene / 5 h / 120 °C / Sealed tube; Inert atmosphere

With sodium hydride; caesium carbonate; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield: 86.6%

5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile (1413064-54-6) → 5-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carbonitrile (1413064-58-0)

Guidance literature:

5-[4-(morpholine-4-carbonyl)-phenylamino]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazole-4-carbonitrile; With hydrogenchloride; water; In ethanol; at 20 ℃;

With sodium hydroxide; In ethanol; water; Cooling with ice;

upstream raw materials:

(2-trimethylethylsilylethoxy)methyl chloride

5-amino-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbonitrile

(4-bromophenyl)(morpholino)methanone

Downstream raw materials:

1-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-3-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carboxylic acid amide

5-[4-(morpholine-4-carbonyl)-phenylamino]-1H-pyrazole-4-carbonitrile