2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

Base Information

• Chemical Name: 2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole
• CAS No.: 1621514-68-8
• Molecular Formula: C₂₁H₁₂F₃N₅S
• Molecular Weight: 423.421

Synonyms:2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

Chemical Property of 2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

There total 3 articles about 2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-bromopyrimidine (4595-59-9) + 2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo[3,2-b][1,2,4]triazole (1621514-58-6) → 2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole (1621514-68-8)

Guidance literature:

With palladium diacetate; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 130 ℃; for 15h; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201402193

Reference yield:

5-phenyl-1H-1,2,4-triazole-3-thiol (3414-94-6) → 2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole (1621514-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 3 h / Reflux

1.2: 0 - 20 °C

2.1: caesium carbonate; palladium diacetate; tricyclohexylphosphine / 1,4-dioxane / 15 h / 130 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; palladium diacetate; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; ethanol; water;

DOI:10.1002/ejoc.201402193

Reference yield:

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (383-53-9) → 2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole (1621514-68-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 3 h / Reflux

1.2: 0 - 20 °C

2.1: caesium carbonate; palladium diacetate; tricyclohexylphosphine / 1,4-dioxane / 15 h / 130 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; palladium diacetate; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; ethanol; water;

DOI:10.1002/ejoc.201402193

upstream raw materials:

5-bromopyrimidine

2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo[3,2-b][1,2,4]triazole

5-phenyl-1H-1,2,4-triazole-3-thiol

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1621514-68-8 2-phenyl-5-(pyrimidin-5-yl)-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

Send

Send

Metric Ton KG G Pound L ML

Send

Send