4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1276045-26-1
• Molecular Formula: C₁₇H₂₅NO₃
• Molecular Weight: 291.39
• Mol file: 1276045-26-1.mol

Synonyms:4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 12 articles about 4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3-methoxyphenyl)magnesium bromide (36282-40-3) + tert-butyl 4-iodopiperidine-1-carboxylate (301673-14-3) → 4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (1276045-26-1)

Guidance literature:

With (1R,2R)-bis(dimethylamino)cyclohexane; cobalt(II) chloride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol503043r

Reference yield: 84.0%

4-(3-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (194669-45-9) → 4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (1276045-26-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; under 10343.2 Torr;

DOI:10.1016/j.bmcl.2010.12.068

Reference yield: 80.0%

1-chloro-3-methoxy-benzene (2845-89-8) + bromo({1-[(tert-butoxy)carbonyl]piperidin-4-yl})zinc (1309607-10-0) → 4-(3-methoxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester (1276045-26-1)

Guidance literature:

With dichloro(1,5-cyclooctadiene)palladium(II); C₃₈H₆₂P₂; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.202016048

upstream raw materials:

4-(3-methoxy-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

3-methoxy-1-iodobenzene

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

3-methoxyphenyl bromide

Downstream raw materials:

4-(3-methoxyphenyl)piperidine

2-ethyl-1-[4-(3-methoxy-phenyl)-piperidin-1-yl]-butan-1-one

1-(4-(3-methoxyphenyl)piperidin-1-yl)-3-methylbutan-1-one

cyclopropyl-[4-(3-methoxy-phenyl)-piperidin-1-yl]-methanone