<2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

Base Information

Chemical Name:<2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide
CAS No.:127516-75-0
Molecular Formula:C₁₉H₁₄BrFN₂O₄S
Molecular Weight:465.3
Hs Code.:

<2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benz<d>isothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

Synonyms:<2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

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Chemical Property of <2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

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Technology Process of <2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

There total 4 articles about <2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 127526-30-1
2-<<<(4-bromo-2-fluorophenyl)methyl>amino>sulfonyl>-α-cyano-β-oxobenzenepropanoic acid ethyl ester

: 127516-75-0
<2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

Guidance literature:: With acetic anhydride; for 0.833333h; Heating;
DOI:10.1021/jm00102a016

Reference yield:

: 128-44-9
saccharin sodium salt

: 127516-75-0
<2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: 73 percent / acetic anhydride / 0.83 h / Heating

With potassium tert-butylate; acetic anhydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00102a016

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 127516-75-0
<2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: 73 percent / acetic anhydride / 0.83 h / Heating

With potassium tert-butylate; acetic anhydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00102a016