7-oxo-7-phenyl-heptanoic acid phenethyl ester

Base Information

• Chemical Name: 7-oxo-7-phenyl-heptanoic acid phenethyl ester
• CAS No.: 1234705-19-1
• Molecular Formula: C₂₁H₂₄O₃
• Molecular Weight: 324.42
• Mol file: 1234705-19-1.mol

Synonyms:7-oxo-7-phenyl-heptanoic acid phenethyl ester

Chemical Property of 7-oxo-7-phenyl-heptanoic acid phenethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 7-oxo-7-phenyl-heptanoic acid phenethyl ester

There total 3 articles about 7-oxo-7-phenyl-heptanoic acid phenethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-phenylethanol (60-12-8) + 2-Benzoylcyclohexanone (3580-38-9) → 7-oxo-7-phenyl-heptanoic acid phenethyl ester (1234705-19-1)

Guidance literature:

With iron(III) chloride; at 80 ℃; for 16h; regioselective reaction; Neat (no solvent);

DOI:10.1002/ejoc.201000140

Reference yield: 95.0%

1-tert-butyldimethylsilyloxy-2-phenylethane (78926-09-7) + 2-Benzoylcyclohexanone (3580-38-9) → 7-oxo-7-phenyl-heptanoic acid phenethyl ester (1234705-19-1)

Guidance literature:

With iron(III) chloride; at 80 ℃; for 16h; regioselective reaction; Neat (no solvent);

DOI:10.1002/ejoc.201000140

Reference yield: 72.0%

2-phenylethanol (60-12-8) + 2-Benzoylcyclohexanone (3580-38-9) → 7-oxo-7-phenyl-heptanoic acid phenethyl ester (1234705-19-1) + 2-Phenylethyl benzoate (94-47-3)

Guidance literature:

With indium(III) triflate; at 80 ℃; for 24h; Neat (no solvent); Inert atmosphere;

DOI:10.1002/asia.200900553

upstream raw materials:

2-phenylethanol

2-Benzoylcyclohexanone

1-tert-butyldimethylsilyloxy-2-phenylethane

Refernces

• 1、 Rao, Chitturi Bhujanga,Rao, Dasireddi Chandra,Babu, Dokuburra Chanti,Venkateswarlu, Yenamandra. "Retro-claisen condensation with FeIII as catalyst under solvent-free conditions". supporting information; experimental part. p. 2855 - 2859. Retrieved 2010/08/05.