1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aS,4S,6S,6aS)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester

Base Information

• Chemical Name: 1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aS,4S,6S,6aS)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester
• CAS No.: 124650-88-0
• Molecular Formula: C₃₆H₃₉N₇O₈
• Molecular Weight: 697.748
• Mol file: 124650-88-0.mol

Synonyms:1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aS,4S,6S,6aS)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester

Chemical Property of 1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aS,4S,6S,6aS)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aS,4S,6S,6aS)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester

There total 4 articles about 1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aS,4S,6S,6aS)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-pentafluorophenyloxycarbonyl-naphthalen-2-yl ester (124650-87-9) + 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine (21950-36-7) → (1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester (124650-88-0)

Guidance literature:

With triethylamine; In chloroform; at 25 ℃; for 24h;

DOI:10.1021/ja960324g

Reference yield: 82.0%

(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-chlorocarbonyl-naphthalen-2-yl ester (124650-91-5) + 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine (21950-36-7) → 1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aS,4S,6S,6aS)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester (124650-88-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 8h; Ambient temperature;

DOI:10.1021/ja00023a036

Reference yield:

(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-pentafluorophenyloxycarbonyl-naphthalen-2-yl ester (124650-87-9) + 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine (21950-36-7) → 2,3,4,5,6-pentafluorophenol (771-61-9) + (1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-{[(3aR,4R,6R,6aR)-6-(6-amino-purin-9-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl]-carbamoyl}-naphthalen-2-yl ester (124650-88-0)

Guidance literature:

With triethylamine; In chloroform-d1; at 25 ℃; Rate constant; also in presence var. amide additives as "templates";

DOI:10.1021/ja00087a063

upstream raw materials:

(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-pentafluorophenyloxycarbonyl-naphthalen-2-yl ester

5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine

(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid 6-chlorocarbonyl-naphthalen-2-yl ester