15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one

Base Information

Chemical Name:15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one
CAS No.:1360600-93-6
Molecular Formula:C₂₇H₂₉N₃O₂
Molecular Weight:427.546
Hs Code.:

Synonyms:15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one

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Chemical Property of 15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one

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Technology Process of 15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one

There total 4 articles about 15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1360600-91-4
15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol

: 1360600-93-6
15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one

Guidance literature:: With Jones reagent; In acetone; at 20 ℃; for 0.333333h;
DOI:10.1016/j.bmc.2012.01.008

Reference yield:

: 1360600-88-9
15β-azido-3-methoxyestra-1,3,5(10)-trien-17-one

: 1360600-93-6
15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium borohydride / methanol; dichloromethane / 3 h

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / 111 °C

3: Jones reagent / acetone / 0.33 h / 20 °C

With copper(l) iodide; Jones reagent; potassium borohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane; acetone; toluene; 3: Jones oxidation;
DOI:10.1016/j.bmc.2012.01.008

Reference yield:

: 17748-68-4
3-methoxy-estra-1,3,5⁽¹⁰⁾,15-tetraen-17-one

: 1360600-93-6
15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; acetic acid / tetrahydrofuran; water / 24 h / 20 °C

2: potassium borohydride / methanol; dichloromethane / 3 h

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / 111 °C

4: Jones reagent / acetone / 0.33 h / 20 °C

With copper(l) iodide; Jones reagent; sodium azide; potassium borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; 1: Michael addition / 4: Jones oxidation;
DOI:10.1016/j.bmc.2012.01.008