15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol

Base Information

Chemical Name:15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol
CAS No.:1360600-91-4
Molecular Formula:C₂₇H₃₁N₃O₂
Molecular Weight:429.562
Hs Code.:

Synonyms:15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol

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Chemical Property of 15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol

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Technology Process of 15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol

There total 3 articles about 15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1360600-89-0
15β-azido-3-methoxyestra-1,3,5(10)-trien-17β-ol

: 536-74-3
phenylacetylene

: 1360600-91-4
15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In toluene; at 111 ℃; for 4h;
DOI:10.1016/j.bmc.2012.01.008

Reference yield:

: 17748-68-4
3-methoxy-estra-1,3,5⁽¹⁰⁾,15-tetraen-17-one

: 1360600-91-4
15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide; acetic acid / tetrahydrofuran; water / 24 h / 20 °C

2: potassium borohydride / methanol; dichloromethane / 3 h

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / 111 °C

With copper(l) iodide; sodium azide; potassium borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1: Michael addition;
DOI:10.1016/j.bmc.2012.01.008

Reference yield:

: 1360600-88-9
15β-azido-3-methoxyestra-1,3,5(10)-trien-17-one

: 1360600-91-4
15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium borohydride / methanol; dichloromethane / 3 h

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / 111 °C

With copper(l) iodide; potassium borohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2012.01.008