2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

Base Information

Chemical Name:2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide
CAS No.:936841-57-5
Molecular Formula:C₂₆H₃₀N₂O₃S
Molecular Weight:450.602
Hs Code.:

Synonyms:2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

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Chemical Property of 2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

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Technology Process of 2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

There total 6 articles about 2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 936841-41-7
2-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

: 88-10-8
N,N-diethylcarbamyl chloride

: 936841-57-5
2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

Guidance literature:: 2-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at 0 ℃; for 1h;

N,N-diethylcarbamyl chloride; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jo062385v

Reference yield:

: 936841-24-6
2-iodo-N-(2-phenylpropan-2-yl)benzenesulfonamide

: 936841-57-5
2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 100 °C

2.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / 0 °C

2.2: 99 percent / tetrahydrofuran / -78 - 20 °C

With potassium phosphate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1021/jo062385v

Reference yield:

: 32366-26-0
cumyl azide

: 936841-57-5
2-(N,N-diethylcarboxamido)-6-phenyl-N-(2-phenylpropan-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 19.8 g / H₂ / Lindlar's catalyst / ethanol / 12 h

2.1: 97 percent / Et₃N / CH₂Cl₂ / 0 °C

3.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 2 h / -78 °C

3.2: 88 percent / I₂ / tetrahydrofuran; cyclohexane / -78 - 20 °C

4.1: 76 percent / K₃PO₄ / Pd(PPh₃)4 / dimethylformamide / 24 h / 100 °C

5.1: n-BuLi; TMEDA / tetrahydrofuran / 1 h / 0 °C

5.2: 99 percent / tetrahydrofuran / -78 - 20 °C

With potassium phosphate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium; triethylamine; Lindlar's catalyst; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/jo062385v