C₁₇H₁₂ClF₃N₄O₂

Base Information

Chemical Name:C₁₇H₁₂ClF₃N₄O₂
CAS No.:1347008-91-6
Molecular Formula:C₁₇H₁₂ClF₃N₄O₂
Molecular Weight:396.756
Hs Code.:

C<sub>17</sub>H<sub>12</sub>ClF<sub>3</sub>N<sub>4</sub>O<sub>2</sub>

Synonyms:C₁₇H₁₂ClF₃N₄O₂

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Chemical Property of C₁₇H₁₂ClF₃N₄O₂

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Technology Process of C₁₇H₁₂ClF₃N₄O₂

There total 3 articles about C₁₇H₁₂ClF₃N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 1347008-89-2
C₁₄H₁₀ClN₃O₂

: 1347008-91-6
C₁₇H₁₂ClF₃N₄O₂

Guidance literature:: C₁₄H₁₀ClN₃O₂; With ammonium acetate; sodium methylate; In propan-1-ol; at 70 ℃; for 1h; Inert atmosphere;

3-bromo-1,1,1-trifluoroacetone; In propan-1-ol; at 85 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.05.051

Reference yield:

: 19235-89-3
4-chloro-pyridine-2-carbonitrile

: 1347008-91-6
C₁₇H₁₂ClF₃N₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 85 °C

2.1: ammonium acetate; sodium methylate / propan-1-ol / 1 h / 70 °C / Inert atmosphere

2.2: 20 h / 85 °C / Inert atmosphere

With ammonium acetate; sodium methylate; potassium carbonate; In propan-1-ol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.051

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1347008-91-6
C₁₇H₁₂ClF₃N₄O₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / 80 °C

1.2: 1 h / 7 °C

2.1: triethylamine; trifluoroacetic anhydride / ethyl acetate / 1.25 h / -5 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 85 °C

4.1: ammonium acetate; sodium methylate / propan-1-ol / 1 h / 70 °C / Inert atmosphere

4.2: 20 h / 85 °C / Inert atmosphere

With thionyl chloride; ammonium acetate; sodium methylate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; In propan-1-ol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.05.051