Galanal B

Base Information

Chemical Name:Galanal B
CAS No.:104113-52-2
Molecular Formula:C₂₀H₃₀O₃
Molecular Weight:318.456
Hs Code.:
DSSTox Substance ID:DTXSID10146281
Nikkaji Number:J1.719.402J,J1.859.117K
Wikidata:Q83011065
Metabolomics Workbench ID:143856
Mol file:104113-52-2.mol

Synonyms:galanal B

Suppliers and Price of Galanal B

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Galanal B

Chemical Property:

Vapor Pressure:7.76E-10mmHg at 25°C
Boiling Point:446.2°Cat760mmHg
Flash Point:237.8°C
Density:1.147g/cm³
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:318.21949481
Heavy Atom Count:23
Complexity:535

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCCC2(C1CCC3(C2CC=C(CC3O)C=O)C=O)C)C
Isomeric SMILES:C[C@]12CCCC([C@@H]1CC[C@@]3([C@@H]2CC=C(C[C@H]3O)C=O)C=O)(C)C

Technology Process of Galanal B

There total 8 articles about Galanal B which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: ((6aR,11aR,11bS)-7-hydroxy-4,4,11b-trimethyl-2,3,4,4a,5,6,6a,7,8,11,11a,11b-dodecahydro-1H-cyclohepta[a]naphthalene-6a,9-diyl)dimethanol

: 104113-52-2
galanal A

: 104086-74-0
galanal A

Guidance literature:: With N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutyl-ammonium chloride; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; water; at 20 ℃; for 6h; Overall yield = 70 %; Inert atmosphere;
DOI:10.1021/ol501121v

Reference yield:

: ((6aR,11aR,11bS)-7-hydroxy-4,4,11b-trimethyl-2,3,4,4a,5,6,6a,7,8,11,11a,11b-dodecahydro-1H-cyclohepta[a]naphthalene-6a,9-diyl)dimethanol

: galanal A

: 104113-52-2
galanal A

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; isothiocyanic acid; tetrabutyl-ammonium chloride; sodium hydrogencarbonate; potassium carbonate; In dichloromethane; at 20 ℃; Overall yield = 70 %;

Reference yield:

: 190264-38-1
2-((1R,2R,4aS,8aS)-2-hydroxy-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)-N-methoxy-N-methylacetamide

: galanal A

: 104113-52-2
galanal A

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride; pyridine / dichloromethane / -78 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

3: toluene / Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

5: bis(cyclopentadienyl)titanium dichloride; zinc / tetrahydrofuran / 20 °C

6: diisobutylaluminium hydride / dichloromethane / -78 °C

7: isothiocyanic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetrabutyl-ammonium chloride; potassium carbonate; sodium hydrogencarbonate / dichloromethane / 20 °C

With pyridine; bis(cyclopentadienyl)titanium dichloride; lithium aluminium tetrahydride; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; isothiocyanic acid; tetrabutyl-ammonium chloride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; dichloromethane; toluene; 3: |Wittig Olefination;