Chemical Property of 1-(2-Chloroacetyl)-5,9b-difluoro-10-hydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate
Chemical Property:
- Appearance/Colour:Distributed as 0.05% ointment.
- Vapor Pressure:0mmHg at 25°C
- Melting Point:-32°C
- Refractive Index:1.551
- Boiling Point:570.7 °C at 760 mmHg
- PKA:12.55±0.70(Predicted)
- Flash Point:298.9 °C
- PSA：80.67000
- Density:1.31 g/cm3
- LogP:4.05110
- Storage Temp.:Refrigerator
- Solubility.:Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly)
- XLogP3:3.7
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:5
- Exact Mass:484.1828081
- Heavy Atom Count:33
- Complexity:964
- Purity/Quality:
-
99%, *data from raw suppliers
HalobetasolPropionate *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)CCl
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Description
Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both
antiinflammatory and antihyperplasia properties. The compound is recommended for
the treatment of moderate to severe corticosteroid-responsive dermatoses and appears
to be particularly effective in patients with plaque psoriasis. Halobetasol propionate is a synthetic glucocorticoid. It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis.
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Uses
Anti-inflammatory; a dermatologic agent commonly used to treat psoriasis
