2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride

Base Information

Chemical Name:2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride
CAS No.:1000608-23-0
Molecular Formula:C₂₂H₂₈N₃O₅PS
Molecular Weight:477.521
Hs Code.:

Synonyms:2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride

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Chemical Property of 2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride

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Technology Process of 2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride

There total 5 articles about 2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 261365-11-1
MB 05032

: 1115-59-9
(S)-alanine ethyl ester hydrochloride

: 108-95-2,27073-41-2
phenol

: 1000608-23-0
2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride

Guidance literature:: MB 05032; With pyridine; thionyl chloride; In 1,2-dichloro-ethane; for 2h; Reflux;

phenol; at 0 - 20 ℃; for 1h;

(S)-alanine ethyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm101035x

Reference yield:

: C₁₇H₁₈ClN₂O₃PS

: 1115-59-9
(S)-alanine ethyl ester hydrochloride

: 1000608-23-0
2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/ja074871l

Reference yield:

: 261365-11-1
MB 05032

: 1000608-23-0
2-amino-4-[2-(5-(O-phenyl)-(N-((S)-1-ethoxycarbonyl)ethyl)phosphonamido)furanyl]-5-isobutylthiazole hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; thionyl chloride / 1,2-dichloro-ethane / Reflux

1.2: 20 °C

2.1: water / 4 h / 20 °C

3.1: thionyl chloride

With pyridine; thionyl chloride; water; In 1,2-dichloro-ethane;
DOI:10.1021/jm101035x