2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene
• CAS No.: 189286-88-2
• Molecular Formula: C₃₁H₃₄N₂O₄S
• Molecular Weight: 530.688

Synonyms:2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene

Chemical Property of 2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene

Chemical Property:

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Technology Process of 2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene

There total 6 articles about 2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(piperidin-4-yl)ethyl chloride (1932-03-2) + 2-(4-methoxyphenyl)-3-[N-(4-hydroxyphenyl)acetamido]-6-methoxy-benzo[b]thiophene (189286-86-0) → 2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene (189286-88-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; for 5h; Ambient temperature;

DOI:10.1021/jm970167b

Reference yield:

N-[4-(benzyloxy)phenyl]acetamide (41927-14-4) → 2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene (189286-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 6 percent / Cu₂O, 2,4,6-collidine / 72 h / Heating

2: 83 percent / H₂, aq. HCl / 5percent Pd/C / ethanol; ethyl acetate / 4 h / 2068.6 Torr

3: 90 percent / Cs₂CO₃ / dimethylformamide / 5 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; copper(I) oxide; hydrogenchloride; hydrogen; caesium carbonate; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm970167b

Reference yield:

2-(4'-methoxyphenyl)-6-methoxybenzothiophene (63675-74-1) → 2-(4-methoxyphenyl)-3-[N-[4-[2-(1-piperidinyl)ethoxy]phenyl]acetamido]-6-methoxybenzo[b]thiophene (189286-88-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / Br₂ / CHCl₃ / 60 °C

2: 6 percent / Cu₂O, 2,4,6-collidine / 72 h / Heating

3: 83 percent / H₂, aq. HCl / 5percent Pd/C / ethanol; ethyl acetate / 4 h / 2068.6 Torr

4: 90 percent / Cs₂CO₃ / dimethylformamide / 5 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; copper(I) oxide; hydrogenchloride; hydrogen; bromine; caesium carbonate; palladium on activated charcoal; In ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm970167b

upstream raw materials:

2-(piperidin-4-yl)ethyl chloride

2-(4-methoxyphenyl)-3-[N-(4-hydroxyphenyl)acetamido]-6-methoxy-benzo[b]thiophene

N-[4-(benzyloxy)phenyl]acetamide

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

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