AcetaMide, N-[4-(phenylMethoxy)phenyl]-

Base Information

• Chemical Name: AcetaMide, N-[4-(phenylMethoxy)phenyl]-
• CAS No.: 41927-14-4
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Hs Code.: 2924299090
• Mol file: 41927-14-4.mol

Synonyms:Essigsaeure-(4-benzyloxy-anilid);4-Acetamino-phenol-benzylaether;4-(benzyloxy)acetanilide;acetic acid-(4-benzyloxy-anilide);N-[4-(benzyloxy)phenyl]acetamide;N-Acetyl-4-benzyloxyaniline;

Chemical Property of AcetaMide, N-[4-(phenylMethoxy)phenyl]-

Chemical Property:

• Vapor Pressure: 2.54E-08mmHg at 25°C
• Boiling Point: 450.9°Cat760mmHg
• Flash Point: 226.5°C
• PSA: 38.33000
• Density: 1.164g/cm³
• LogP: 3.29700

Purity/Quality:

99% ^*data from raw suppliers

N-(4-(Benzyloxy)phenyl)acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of AcetaMide, N-[4-(phenylMethoxy)phenyl]-

There total 10 articles about AcetaMide, N-[4-(phenylMethoxy)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-acetaminophenol (103-90-2,8055-08-1) + benzyl bromide (100-39-0) → N-[4-(benzyloxy)phenyl]acetamide (41927-14-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃;

DOI:10.1021/acs.jmedchem.6b00759

Reference yield: 98.0%

1-(4-(benzyloxy)phenyl)ethan-1-one oxime (75408-90-1) → N-[4-(benzyloxy)phenyl]acetamide (41927-14-4)

Guidance literature:

1-(4-(benzyloxy)phenyl)ethan-1-one oxime; With fluorosulfonyl fluoride; triethylamine; In acetonitrile; at 20 ℃;

With hydrogenchloride; In water; acetonitrile; at 20 ℃;

DOI:10.1002/ejoc.201900844

Reference yield: 98.0%

→ N-[4-(benzyloxy)phenyl]acetamide (41927-14-4)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃;

upstream raw materials:

4-acetaminophenol

benzyl chloride

sodium 4-acetylaminophenolate

p-benzyloxyaniline

Downstream raw materials:

2-(4-methoxyphenyl)-3-[N-(4-benzyloxyphenyl)acetamido]-6-methoxy-benzo[b]thiophene

6-amino-4-<(4-benzyloxyphenyl)amino>quinazoline

4-benzyloxyaniline hydrochloride

C₂₂H₁₇N₃O₅

Refernces

• 1、 Nielsen, John,Tung, Truong Thanh. "Amide bond formation in aqueous solution: Direct coupling of metal carboxylate salts with ammonium salts at room temperature". supporting information. p. 10073 - 10080. Retrieved 2021/12/10.
• 2、 Ibrahim, Tarek S.,Hawwas, Mohamed M.,Malebari, Azizah M.,Taher, Ehab S.,Omar, Abdelsattar M.,O’boyle, Niamh M.,McLoughlin, Eavan,Abdel-Samii, Zakaria K.,Elshaier, Yaseen A. M. M.. "Potent quinoline-containing combretastatin a-4 analogues: Design, synthesis, antiproliferative, and anti-tubulin activity". . p. 1 - 22. Retrieved 2020/11/19.