t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate

Base Information

• Chemical Name: t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate
• CAS No.: 1530778-24-5
• Molecular Formula: C₁₉H₃₀O₈S
• Molecular Weight: 418.508

Synonyms:t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate

Chemical Property of t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate

Chemical Property:

• Boiling Point: 517.7±45.0 °C(Predicted)
• Density: 1.168±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Tos-PEG3-CH2COOtBu 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate

There total 8 articles about t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

p-toluenesulfonyl chloride (98-59-9) + tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate (518044-31-0) → t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate (1530778-24-5)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

Reference yield: 81.5%

bromoacetic acid tert-butyl ester (5292-43-3) + 8-tosyloxy-3,6-dioxaoctanol (77544-68-4) → t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate (1530778-24-5)

Guidance literature:

With tetrabutylammomium bromide; potassium hydroxide; In toluene; at 20 ℃; for 12h;

Reference yield:

bromoacetic acid tert-butyl ester (5292-43-3) → t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate (1530778-24-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol; tert-butyl methyl ether / 1.5 h / 20 °C

3.1: pyridine / 16 h / 0 - 20 °C

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; In pyridine; ethanol; tert-butyl methyl ether; tert-butyl alcohol;

upstream raw materials:

triethylene glycol monobenzyl ether

bromoacetic acid tert-butyl ester

p-toluenesulfonyl chloride

tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate

Downstream raw materials:

(2S,4R)-1-((S)-2-(tert-butyl)-20-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)-15-methyl-4-oxo-6,9,12-trioxa-3,15-diazaicosan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-1-((S)-2-(tert-butyl)-14-(4-(5-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)pentyl)piperazin-1-yl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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