Hydroxy-PEG3-t-butyl acetate

Base Information

• Chemical Name: Hydroxy-PEG3-t-butyl acetate
• CAS No.: 518044-31-0
• Molecular Formula: C12H24O6
• Molecular Weight: 264.319
• Hs Code.: 2942000090
• Mol file: 518044-31-0.mol

Synonyms:Hydroxy-PEG3-t-butyl acetate;Hydroxy-PEG3-CH2CO2tBu

Chemical Property of Hydroxy-PEG3-t-butyl acetate

Chemical Property:

• Boiling Point: 351.2±27.0 °C(Predicted)
• PKA: 14.36±0.10(Predicted)
• PSA: 74.22000
• Density: 1.071±0.06 g/cm3(Predicted)
• LogP: 0.37020

Purity/Quality:

99%, ^*data from raw suppliers

Hydroxy-Peg3-CH2CO2tBu ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Hydroxy-PEG3-CH2CO2tBu is a PEG linker containing a hydroxyl group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of Hydroxy-PEG3-t-butyl acetate

There total 4 articles about Hydroxy-PEG3-t-butyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester (1443467-88-6) → tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate (518044-31-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; tert-butyl methyl ether; at 20 ℃; for 1.5h;

Reference yield: 64.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 2,2'-[1,2-ethanediylbis(oxy)]bisethanol (112-27-6) → tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate (518044-31-0)

Guidance literature:

2,2'-[1,2-ethanediylbis(oxy)]bisethanol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere;

Reference yield:

triethylene glycol monobenzyl ether (55489-58-2,1201808-31-2) → tert-butyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)acetate (518044-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C

1.2: 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol; tert-butyl methyl ether / 1.5 h / 20 °C

With palladium 10% on activated carbon; potassium tert-butylate; hydrogen; In ethanol; tert-butyl methyl ether; tert-butyl alcohol;

upstream raw materials:

bromoacetic acid tert-butyl ester

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

triethylene glycol monobenzyl ether

1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid tert-butyl ester

Downstream raw materials:

t-butyl [2-(2-{2-[(4-methylbenzene-1-sulfonyl)oxy]ethoxy}ethoxy)ethoxy]acetate

(2S,4R)-1-((S)-2-(tert-butyl)-20-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)-15-methyl-4-oxo-6,9,12-trioxa-3,15-diazaicosan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(2S,4R)-1-((S)-2-(tert-butyl)-14-(4-(5-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)pentyl)piperazin-1-yl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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