1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine

Base Information

Chemical Name:1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine
CAS No.:133671-21-3
Molecular Formula:C₂₆H₃₁Cl₂N₃O₃
Molecular Weight:504.456
Hs Code.:

Synonyms:1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine

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Chemical Property of 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine

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Technology Process of 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine

There total 5 articles about 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 133671-15-5
1-(Carbobenzyloxy)-trans-4-(methylamino)-3-pyrrolidinylpiperidine

: 133671-21-3
1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 20h;
DOI:10.1021/jo00009a038

Reference yield:

: 694-05-3
1,2,3,6-tetrahydropyridine

: 133671-21-3
1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 10percent aq. Na₂CO₃ / 2 h / 0 °C

2: 92 percent / m-CPBA / CH₂Cl₂ / 4 h / 0 deg C to r.t.

4: 79 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h

With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00009a038

Reference yield:

: 66207-08-7,1624258-63-4
3,4-epoxy-piperidine-1-carboxylic acid benzyl ester

: 133671-21-3
1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorophenylacetamido)-3-pyrrolidinylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

2: 79 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 h

With 1,1'-carbonyldiimidazole; In tetrahydrofuran;
DOI:10.1021/jo00009a038