(R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

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Chemical Name:(R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester
CAS No.:1027428-89-2
Molecular Formula:C₄₇H₇₈N₄O₈Si₂
Molecular Weight:883.329
Hs Code.:

(R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

Synonyms:(R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

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Chemical Property of (R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

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Technology Process of (R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

There total 14 articles about (R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 284470-01-5
(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

: 1027428-89-2
(R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 2h; under 760 Torr;
DOI:10.1016/S0040-4020(00)00170-8

Reference yield:

: 124-13-0
Octanal

: 1027428-89-2
(R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 54 percent / N-tosyl-D-Val-OH; BH₃*THF / tetrahydrofuran / 1 h / -78 °C

2: 93 percent / aq. NaOH / methanol / 3.5 h / 20 °C

3: 32 mg / DEPC; DIPEA / dimethylformamide / 4.5 h / 0 - 20 °C

4: 34 mg / DCC; DMAP / toluene / 39 h / 20 °C

5: H₂ / Pd/C / methanol / 2 h / 20 °C / 760 Torr

With dmap; sodium hydroxide; borane-THF; N-((4-methylphenyl)sulfonyl)-D-valine; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 1: aldol reaction / 2: Hydrolysis / 3: Condensation / 4: Condensation / 5: Hydrogenolysis;
DOI:10.1016/S0040-4020(00)00170-8

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1027428-89-2
(R)-2-Amino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / DIPEA; DMAP / CH₂Cl₂ / 17.5 h / 0 - 20 °C

2: aq. LiOH / tetrahydrofuran / 1.5 h / 0 - 20 °C

3: 34 mg / DCC; DMAP / toluene / 39 h / 20 °C

4: H₂ / Pd/C / methanol / 2 h / 20 °C / 760 Torr

With dmap; lithium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: Condensation / 2: Hydrolysis / 3: Condensation / 4: Hydrogenolysis;
DOI:10.1016/S0040-4020(00)00170-8