(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

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Chemical Name:(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester
CAS No.:284470-01-5
Molecular Formula:C₅₅H₈₄N₄O₁₀Si₂
Molecular Weight:1017.46
Hs Code.:

(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

Synonyms:(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

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Chemical Property of (R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

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Technology Process of (R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

There total 12 articles about (R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171287-62-0
[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-yl]-carbamic acid benzyl ester

: 284470-01-5
(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd(OH)2/C / methanol / 1.5 h / 20 °C / 760 Torr

2: 32 mg / DEPC; DIPEA / dimethylformamide / 4.5 h / 0 - 20 °C

3: 34 mg / DCC; DMAP / toluene / 39 h / 20 °C

With dmap; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; palladium dihydroxide; In methanol; N,N-dimethyl-formamide; toluene; 1: Hydrogenolysis / 2: Condensation / 3: Condensation;
DOI:10.1016/S0040-4020(00)00170-8

Reference yield:

: 937242-43-8
(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid

: 284470-00-4
(S)-3-Hydroxy-2,2-dimethyl-decanoic acid [(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-yl]-amide

: 284470-01-5
(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 20 ℃; for 39h;
DOI:10.1016/S0040-4020(00)00170-8

Reference yield:

: 124-13-0
Octanal

: 284470-01-5
(R)-2-Benzyloxycarbonylamino-6-[formyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid (S)-1-{1-[(S)-1-(tert-butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-ylcarbamoyl]-1-methyl-ethyl}-octyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 54 percent / N-tosyl-D-Val-OH; BH₃*THF / tetrahydrofuran / 1 h / -78 °C

2: 93 percent / aq. NaOH / methanol / 3.5 h / 20 °C

3: 32 mg / DEPC; DIPEA / dimethylformamide / 4.5 h / 0 - 20 °C

4: 34 mg / DCC; DMAP / toluene / 39 h / 20 °C

With dmap; sodium hydroxide; borane-THF; N-((4-methylphenyl)sulfonyl)-D-valine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; diethyl dicarbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; 1: aldol reaction / 2: Hydrolysis / 3: Condensation / 4: Condensation;
DOI:10.1016/S0040-4020(00)00170-8