ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

Base Information

Chemical Name:ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate
CAS No.:1428526-34-4
Molecular Formula:C₂₀H₂₁N₄O₅P
Molecular Weight:428.384
Hs Code.:

Synonyms:ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

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Chemical Property of ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

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Technology Process of ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

There total 8 articles about ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1428526-32-2
diethyl 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

: 1428526-34-4
ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 20 ℃;

Reference yield:

: 850363-42-7
1-(4-bromophenyl)-N-(tert-butoxycarbonyl)ethylamine

: 1428526-34-4
ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 100 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: triethylamine; HATU / acetonitrile / 2 h / 20 °C

4: trimethylsilyl bromide / dichloromethane / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; triethylamine; HATU; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;

Reference yield:

: 24358-62-1
1-(4-bromophenyl)ethylamine

: 1428526-34-4
ethyl hydrogen 4-(1-(4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)ethyl)phenylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 °C

1.2: 0 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 100 °C

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.1: triethylamine; HATU / acetonitrile / 2 h / 20 °C

5.1: trimethylsilyl bromide / dichloromethane / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; triethylamine; HATU; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;