1-(4-Bromophenyl)ethanamine

Base Information

• Chemical Name: 1-(4-Bromophenyl)ethanamine
• CAS No.: 24358-62-1
• Molecular Formula: C8H10BrN
• Molecular Weight: 200.078
• Hs Code.: 29214990
• European Community (EC) Number: 246-200-3
• DSSTox Substance ID: DTXSID10947215
• Nikkaji Number: J287.229C,J578.958C
• Mol file: 24358-62-1.mol

Synonyms:24358-62-1;1-(4-Bromophenyl)ethylamine;1-(4-Bromophenyl)ethanamine;4-Bromo-alpha-methylbenzylamine;1-(4-bromophenyl)ethan-1-amine;[1-(4-Bromophenyl)ethyl]amine;EINECS 246-200-3;p-Bromo-alpha-methylbenzylamine;C8H10BrN;(+)-p-Bromo-.alpha.-phenethylamine;MFCD00025548;Benzenemethanamine, 4-bromo-.alpha.-methyl-, (R)-;(-)-1-(4-Bromophenyl)ethylamine;4-Bromo-A-methylbenzylamine;(S)-1-(4-Bromopheny)ethylamine;EINECS 256-245-0;MFCD00066025;1-AMINO-1-(4-BROMOPHENYL)ETHANE;(+/-)-1-(4-BROMOPHENYL)ETHYLAMINE;SCHEMBL256802;1-(4-bromophenyl)-ethylamine;1-(4-Bromophenyl)ethanamine #;1-(4-Bromo-Phenyl)-Ethylamine;1-(4-bromophenyl)-1-ethanamine;DTXSID10947215;4-Bromo- alpha -methylbenzylamine;HMS1788B09;(+)-1-(4-Bromophenyl)ethylamine;BCP09414;BBL034684;STL426841;(S)-(-)-4-Bromo-a-phenylethylamine;4-Bromo-alpha-methylbenzylamine, 98%;AKOS000264343;AKOS016050388;CS-W019475;DS-1192;SB36321;SB77443;SB78170;(rac)-4-bromo-alpha-methylbenzyl amine;AC-29349;SY009349;SY009358;SY020147;TS-02822;(^+)-1-(4-Bromophenyl)ethylamine, 96%;AM20060823;B2266;FT-0601947;FT-0605185;FT-0605664;EN300-10101;A18516;H10501;J-015463;J-502123;J-502349;Z56347162;Benzenemethanamine, 4-bromo-.alpha.-methyl-, (.alpha.R)-

Chemical Property of 1-(4-Bromophenyl)ethanamine

Chemical Property:

• Appearance/Colour: Clear colorless liquid
• Vapor Pressure: 0.0134mmHg at 25°C
• Refractive Index: 1.5665 - 1.5685
• Boiling Point: 258.855 °C at 760 mmHg
• PKA: 8.82±0.10(Predicted)
• Flash Point: 110.352 °C
• PSA: 26.02000
• Density: 1.401 g/cm³
• LogP: 3.16910
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 198.99966
• Heavy Atom Count: 10
• Complexity: 97.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Bromophenyl)ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=C(C=C1)Br)N
• Uses: 4-Bromo-α-methylbenzylamine acid may be used in chemical synthesis studies.

Technology Process of 1-(4-Bromophenyl)ethanamine

There total 31 articles about 1-(4-Bromophenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

p-bromoacetophenone oxime (59862-55-4,73744-33-9,5798-71-0) → 1-(4-bromophenyl)ethylamine (24358-62-1)

Guidance literature:

With iron oxide; zirconium(IV) chloride; sodium cyanoborohydride; In neat (no solvent); at 75 - 80 ℃; for 0.75h;

DOI:10.1007/s13738-014-0550-3

Reference yield: 91.0%

para-bromoacetophenone (99-90-1) → 1-(4-bromophenyl)ethylamine (24358-62-1)

Guidance literature:

With 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; ammonium formate; In methanol; at 80 ℃; for 12h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201303541

Reference yield: 91.0%

→ 1-(4-bromophenyl)ethylamine (24358-62-1)

Guidance literature:

With ammonium formate; In methanol; at 80 ℃; for 0.166667h; Inert atmosphere;

With formic acid; C₂₉H₃₂ClIrNO; triethylamine; In methanol; at 80 ℃;

upstream raw materials:

p-bromoacetophenone oxime

para-bromoacetophenone

formamide

1-(4-bromophenyl)ethanone O-methyl oxime

Downstream raw materials:

4-bromophenacylamine

3-[1-(4-bromo-phenyl)-ethyl]-2-thioxo-thiazolidin-4-one

1-(4-Bromo-phenyl)-ethylamine

1-(4-Bromo-phenyl)-ethylamine

Refernces

• 1、 Basso, Ernani A.,Fernandes, Cleverton de S.,Francisco, Camila B.,Gauze, Gisele de F.,Rittner, Roberto. "Rapid Synthesis of Primary Amines from Ketones using Choline Chloride/Urea Deep Eutectic as a Reaction Medium". . . Retrieved 2021/12/29.
• 2、 Chu, Benfa,Fang, Lili,Guo, Shan,Qi, Bing,Shi, Pengfei,Wang, Qi,Zhu, Jin. "Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant". supporting information. . Retrieved 2020/03/10.