tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate
CAS No.:1262008-82-1
Molecular Formula:C₂₆H₂₅F₃N₂O₅
Molecular Weight:502.49
Hs Code.:

Synonyms:tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

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Chemical Property of tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

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Technology Process of tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

There total 7 articles about tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215119-25-7
3-(chloromethyl)-5-(trifluoromethoxy)benzonitrile

: 1262008-53-6
tert-butyl 2-(8-hydroxy-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262008-82-1
tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: With caesium carbonate; In ISOPROPYLAMIDE; at 70 ℃; for 3h; sealed scintillation vial;

Reference yield:

: 1262008-52-5
tert-butyl 2-(8-(benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262008-82-1
tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

2: caesium carbonate / ISOPROPYLAMIDE / 3 h / 70 °C / sealed scintillation vial

With ammonium formate; caesium carbonate; 20 % Pd(OH)2/C; In methanol; ISOPROPYLAMIDE;

Reference yield:

: 1262008-98-9
tert-butyl 3-(5-(benzyloxy)-1-(2-hydroxyethyl)-1H-indol-2-yl)acrylate

: 1262008-82-1
tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: cesium fluoride / tetrahydrofuran / 100 °C / sealed tube

2: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

3: caesium carbonate / ISOPROPYLAMIDE / 3 h / 70 °C / sealed scintillation vial

With ammonium formate; caesium carbonate; cesium fluoride; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; ISOPROPYLAMIDE;