2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

Base Information

Chemical Name:2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid
CAS No.:1262007-76-0
Molecular Formula:C₂₂H₁₇F₃N₂O₅
Molecular Weight:446.383
Hs Code.:

Synonyms:2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

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Chemical Property of 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

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Technology Process of 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

There total 7 articles about 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262008-82-1
tert-butyl 2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262007-76-0
2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

Guidance literature:: With rac-cysteine; trifluoroacetic acid; In 1,4-dioxane; at 23 ℃; for 3h; sealed scintillation vial;

Reference yield:

: 1262008-52-5
tert-butyl 2-(8-(benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262007-76-0
2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

2: caesium carbonate / ISOPROPYLAMIDE / 3 h / 70 °C / sealed scintillation vial

3: trifluoroacetic acid; rac-cysteine / 1,4-dioxane / 3 h / 23 °C / sealed scintillation vial

With rac-cysteine; ammonium formate; caesium carbonate; trifluoroacetic acid; 20 % Pd(OH)2/C; In 1,4-dioxane; methanol; ISOPROPYLAMIDE;

Reference yield:

: 1262008-98-9
tert-butyl 3-(5-(benzyloxy)-1-(2-hydroxyethyl)-1H-indol-2-yl)acrylate

: 1262007-76-0
2-(8-(3-cyano-5-(trifluoromethoxy)benzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: cesium fluoride / tetrahydrofuran / 100 °C / sealed tube

2: ammonium formate / 20 % Pd(OH)2/C / methanol / 0.5 h / 60 °C / microwave irradiation

3: caesium carbonate / ISOPROPYLAMIDE / 3 h / 70 °C / sealed scintillation vial

4: trifluoroacetic acid; rac-cysteine / 1,4-dioxane / 3 h / 23 °C / sealed scintillation vial

With rac-cysteine; ammonium formate; caesium carbonate; cesium fluoride; trifluoroacetic acid; 20 % Pd(OH)2/C; In tetrahydrofuran; 1,4-dioxane; methanol; ISOPROPYLAMIDE;