N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine

Base Information

Chemical Name:N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine
CAS No.:245762-28-1
Molecular Formula:C₂₇H₂₉FN₂O₂
Molecular Weight:432.538
Hs Code.:

Synonyms:N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine

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Chemical Property of N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine

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Technology Process of N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine

There total 5 articles about N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 3246-03-5
N-[2-(2'-(methoxy)-phenoxy)-ethyl]-benzylamine

: 191013-68-0
3-(3-Bromopropyl)-5-fluoro-1H-indole

: 245762-28-1
N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 100 ℃; for 16h;
DOI:10.1021/jm0304010

Reference yield:

: 90-05-1
2-methoxy-phenol

: 245762-28-1
N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / Ph₃P; DIAD / tetrahydrofuran / 18 h

2: 96 percent / TFA / CH₂Cl₂ / 12 h / 20 °C

3: 58 percent / Et₃N / dimethylsulfoxide / 16 h / 100 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1: Mitsunobu reaction;
DOI:10.1021/jm0304010

Reference yield:

: 121496-39-7
N-(tert-butoxycarbonyl)-N-benzylethanolamine

: 245762-28-1
N-[3-(5-fluoro-1H-indol-3-yl)propyl]-N-[2-(2-methoxyphenoxy)ethyl]benzylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / Ph₃P; DIAD / tetrahydrofuran / 18 h

2: 96 percent / TFA / CH₂Cl₂ / 12 h / 20 °C

3: 58 percent / Et₃N / dimethylsulfoxide / 16 h / 100 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 1: Mitsunobu reaction;
DOI:10.1021/jm0304010