3246-03-5Relevant articles and documents
Novel acetylcholinesterase inhibitory derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating nervous system diseases containing the same as an active ingredient
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Paragraph 0282; 0293-0297, (2019/02/09)
The present invention relates to a novel acetylcholinesterase inhibiting derivative, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disease containing the same as an active ingredient. The compound, a
Synthesis of impurity A in Carvedilol: a β-adrenergic receptor
Madhusudhan,Naidu,Kumar,Satyanarayana,Balraju
experimental part, p. 741 - 745 (2009/12/24)
Carvedilol is prepared by different synthetic approaches. Almost in all the approaches the major impurities that are known in the literature A, B, C, D and E are listed in European pharmacopoeia. The control of pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. In this publication, a description of these impurities and their origins in Carvedilol process are presented along with the preparation of impurity A.
Process and intermediates for preparing 1-[9'H-carbazol-4'-yloxy]-3-[ 2''-(2'''- methoxy -phenoxy)-ethyl)-amino]-propan-2-ol[carvedilol]
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, (2008/06/13)
A subject matter of the invention is a process for preparing 1-[9'H-carbazol-4'-yloxy]-3-[{2''-(2'''--phenoxy)- ethyl}-amino]-propan-2-ol as well as the R or S enantiomer thereof and mixtures of the enantiomers and acid addition salts of these compounds, in which a) 4-(oxiranylmethoxy)-9H-carbazole or the R or S enantiomer thereof is reacted with N-[2-(2'--phenoxy)-ethyl] -benzylamine in a protic organic solvent, and the thus formed 1-[N-{benzyl}-2'-({2''--phenoxy)-ethyl}-amino]-3-[9'''H-carbazol-4'''-yloxy] -propan-2-ol [benzyl-carvedilol] is debenzylated by catalytic hydrogenation or b) the N-[2-(2'--phenoxy) -ethyl]-benzylamine is reacted with epichlorohydrin, the thus formed 1-[N-{benzyl}-2'-({2''--phenoxy)-ethyl}-amino]-3-[chloro] -propan-2-ol is reacted with 4-(hydroxy)-9H-carbazole and the thus formed 1-[N-{benzyl}-2'-({2''--phenoxy)-ethyl}- amino]-3-[9'''H-carbazol-4'''-yloxy]-propan-2-ol is debenzylated by catalytic hydrogenation