trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide

Base Information

Chemical Name:trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide
CAS No.:1354933-75-7
Molecular Formula:C₂₁H₃₂N₄O₂
Molecular Weight:372.511
Hs Code.:

Synonyms:trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide

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Chemical Property of trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide

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Technology Process of trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide

There total 4 articles about trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: trans-4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexylamine trihydrochloride

: 64-19-7,77671-22-8
acetic acid

: 1354933-75-7
trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide

Guidance literature:: trans-4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexylamine trihydrochloride; acetic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

With sodium hydroxide; In water; N,N-dimethyl-formamide; Cooling with ice;

Reference yield:

: 209160-83-8
7-piperazin-1-yl-furo[2,3-c]pyridine

: 1354933-75-7
trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; acetic acid / platinum(IV) oxide / methanol / 24 h / 20 °C

2.1: triethylamine / dichloromethane; methanol / 0.5 h / 20 °C

2.2: 4 h / 20 °C

2.3: Cooling with ice

3.1: hydrogenchloride; water / dichloromethane; 1,4-dioxane / 3.5 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 4 h / 20 °C

4.2: Cooling with ice

With hydrogenchloride; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1354934-84-1
7-(piperazin-1-yl)-2,3-dihydro-furo[2,3-c]pyridine

: 1354933-75-7
trans-N-(4-{2-[4-(2,3-dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl}cyclohexyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane; methanol / 0.5 h / 20 °C

1.2: 4 h / 20 °C

1.3: Cooling with ice

2.1: hydrogenchloride; water / dichloromethane; 1,4-dioxane / 3.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 4 h / 20 °C

3.2: Cooling with ice

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;