(S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester
• CAS No.: 1020673-57-7
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 1020673-57-7.mol

Synonyms:(S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester

Chemical Property of (S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester

There total 2 articles about (S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(2-hydroxy-ethyl)-(2-hydroxy-2-phenyl-ethyl)-carbamic acid tert-butyl ester (942123-01-5) → (S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester (1020673-57-7)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃;

Reference yield:

C15H19NO3 → (S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester (1020673-57-7) + C15H21NO3

Guidance literature:

With di[(η-1,2,5,6)-1,5-cyclooctadiene] rhodium hexafluoroantimonate; hydrogen; C₄₅H₃₉O₂P; In dichloromethane; at 20 ℃; for 12h; under 38002.6 Torr; Optical yield = 75 percent ee;

DOI:10.1039/d1sc04288b

Reference yield: 78.0%

(S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester (1020673-57-7) → (2S)-2-phenylmorpholine (74572-15-9)

Guidance literature:

(S)-2-phenyl-morpholine-4-carboxylic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

With sodium hydroxide; In water; pH=12 - 14; Product distribution / selectivity;

upstream raw materials:

(S)-(2-hydroxy-ethyl)-(2-hydroxy-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Downstream raw materials:

(2S)-2-phenylmorpholine