(S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid

Base Information

Chemical Name:(S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid
CAS No.:851314-95-9
Molecular Formula:C₁₄H₁₆F₄O₄
Molecular Weight:324.272
Hs Code.:

Synonyms:(S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid

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Chemical Property of (S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid

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Technology Process of (S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid

There total 7 articles about (S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 851314-94-8
(αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

: 851314-95-9
(S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid

Guidance literature:: With potassium hydroxide; In methanol; at 70 ℃; for 15h;
DOI:10.1021/jo061839l

Reference yield:

: 217196-31-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid

: 851314-95-9
(S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / TsOH / toluene; H₂O / 3 h / 110 °C

2: 50 percent / TBAF / toluene; tetrahydrofuran / 0.5 h / -20 - 20 °C

3: 97 percent / KOH / methanol / 15 h / 70 °C

With potassium hydroxide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/jo061839l

Reference yield:

: 566920-34-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid ethyl ester

: 851314-95-9
(S)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 94 g / NaOH / tetrahydrofuran; H₂O / cooling

2: 96 percent / TsOH / toluene; H₂O / 3 h / 110 °C

3: 50 percent / TBAF / toluene; tetrahydrofuran / 0.5 h / -20 - 20 °C

4: 97 percent / KOH / methanol / 15 h / 70 °C

With potassium hydroxide; sodium hydroxide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/jo061839l