(αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

Base Information

Chemical Name:(αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester
CAS No.:851314-94-8
Molecular Formula:C₂₉H₃₈F₄O₄Si
Molecular Weight:554.697
Hs Code.:

Synonyms:(αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

There total 5 articles about (αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 851314-93-7
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid (1R,2S)-2-phenylcyclohexyl ester

: 81290-20-2
(trifluoromethyl)trimethylsilane

: (αS)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

: 851314-94-8
(αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; toluene; at -20 - 20 ℃; for 0.5h;
DOI:10.1021/jo061839l

Reference yield:

: 217196-31-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid

: 851314-94-8
(αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / TsOH / toluene; H₂O / 3 h / 110 °C

2: 50 percent / TBAF / toluene; tetrahydrofuran / 0.5 h / -20 - 20 °C

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; water; toluene;
DOI:10.1021/jo061839l

Reference yield:

: 566920-34-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid ethyl ester

: 851314-94-8
(αR)-5-fluoro-2-methoxy-γ,γ-dimethyl-α-(trifluoromethyl)-α-[(trimethylsilyl)oxy]-benzenebutanoic acid (1R,2S)-2-phenylcyclohexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 g / NaOH / tetrahydrofuran; H₂O / cooling

2: 96 percent / TsOH / toluene; H₂O / 3 h / 110 °C

3: 50 percent / TBAF / toluene; tetrahydrofuran / 0.5 h / -20 - 20 °C

With sodium hydroxide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; water; toluene;
DOI:10.1021/jo061839l