5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid

Base Information

• Chemical Name: 5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid
• CAS No.: 109013-21-0
• Molecular Formula: C₁₄H₁₈N₄O
• Molecular Weight: 258.323
• Mol file: 109013-21-0.mol

Synonyms:5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid

Chemical Property of 5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid

There total 5 articles about 5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

isopropylamine (75-31-0) + 5-Amino-3-methyl-4-phenyl-1H-pyrazol-1-thiocarbonsaeure-S-methylester (109013-32-3) → 5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid (109013-21-0)

Guidance literature:

In methanol; for 0.5h; Ambient temperature;

Reference yield: 85.0%

3-amino-5-methyl-4-phenyl-1Н-pyrazole (31924-81-9) + Isopropyl isocyanate (1795-48-8) → 5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid (109013-21-0)

Guidance literature:

In acetone; for 12h; Ambient temperature;

Reference yield:

1-phenyl-1-cyanopropan-2-one (4468-48-8) → 5-Amino-3-methyl-N-(1-methylethyl)-4-phenyl-1H-pyrazol-1-carboxamid (109013-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / ethanol / 1.) 15 min, reflux; 2.) 10 d, RT

2: 85 percent / acetone / 12 h / Ambient temperature

In ethanol; acetone;

upstream raw materials:

isopropylamine

5-Amino-3-methyl-4-phenyl-1H-pyrazol-1-thiocarbonsaeure-S-methylester

3-amino-5-methyl-4-phenyl-1Н-pyrazole

Isopropyl isocyanate

Downstream raw materials:

7-Methyl-3-(1-methylethyl)-8-phenyl-pyrazolo<5,1-d>-1,2,3,5-tetrazin-4(3H)-on