4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid

Base Information

Chemical Name:4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid
CAS No.:92548-59-9
Molecular Formula:C₁₅H₁₇N₃O₆S
Molecular Weight:367.382
Hs Code.:

Synonyms:4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid

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Chemical Property of 4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid

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Technology Process of 4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid

There total 4 articles about 4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₁₆H₁₉N₃O₆S

: 92548-59-9
4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 0 ℃; for 48h;
DOI:10.1038/s41467-019-09387-4

Reference yield:

: 108-30-5
succinic acid anhydride

active charcoal: active charcoal

: 127-69-5
sulfisoxazole

: 92548-59-9
4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid

Guidance literature:: With dmap; In sodium hydrogencarbonate; N,N-dimethyl-formamide;

Reference yield:

: 127-69-5
sulfisoxazole

: 92548-59-9
4-((4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / chloroform / 2 h / 0 - 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 48 h / 0 °C

With dmap; lithium hydroxide monohydrate; triethylamine; In tetrahydrofuran; chloroform; water;
DOI:10.1038/s41467-019-09387-4