4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid

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Chemical Name:4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid
CAS No.:1275596-63-8
Molecular Formula:C₁₇H₂₂N₅O₆P
Molecular Weight:423.365
Hs Code.:

Synonyms:4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid

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Chemical Property of 4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid

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Technology Process of 4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid

There total 7 articles about 4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1275596-59-2
4-{[[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid methyl ester

: 1275596-63-8
4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid

Guidance literature:: 4-{[[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid methyl ester; With platinum(IV) oxide; hydrogen; trifluoroacetic acid; at 20 ℃; for 24h; under 2585.81 Torr;

With sodium hydroxide; at 20 ℃; for 12h;

With hydrogenchloride; In water; pH=1;
DOI:10.1016/j.bmc.2010.12.003

Reference yield:

: 1275596-56-9
4-{[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-ylamino]-methyl}-benzoic acid methyl ester

: 1275596-63-8
4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 20 °C / Molecular sieve

2.1: N-tert-butylaminoborane; acetic acid / 2 h / 20 °C

3.1: trimethylsilyl bromide / dichloromethane / 72 h / 20 °C / Inert atmosphere

3.2: 2 h

4.1: platinum(IV) oxide; hydrogen; trifluoroacetic acid / 24 h / 20 °C / 2585.81 Torr

4.2: 12 h / 20 °C

4.3: pH 1

With platinum(IV) oxide; trimethylsilyl bromide; N-tert-butylaminoborane; hydrogen; acetic acid; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2010.12.003

Reference yield:

: 1275596-57-0
4-({[2-(diethoxy-phosphoryl)-ethyl]-[2-(2,2-dimethyl-propionylamino)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl]-amino}-methyl)-benzoic acid methyl ester

: 1275596-63-8
4-{[(2-amino-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-6-yl)-(2-phosphono-ethyl)-amino]-methyl}-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl bromide / dichloromethane / 72 h / 20 °C / Inert atmosphere

1.2: 2 h

2.1: platinum(IV) oxide; hydrogen; trifluoroacetic acid / 24 h / 20 °C / 2585.81 Torr

2.2: 12 h / 20 °C

2.3: pH 1

With platinum(IV) oxide; trimethylsilyl bromide; hydrogen; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2010.12.003