(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid

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Chemical Name:(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid
CAS No.:866343-66-0
Molecular Formula:C₂₆H₃₉ClN₂O₈
Molecular Weight:543.057
Hs Code.:

Synonyms:(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid

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Chemical Property of (S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid

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Technology Process of (S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid

There total 10 articles about (S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

: C₂₉H₄₃ClN₂O₈

: 866343-66-0
(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112364

Reference yield:

: 866343-65-9
(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid benzyl ester

: 866343-66-0
(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 3h; under 760 Torr;
DOI:10.1002/chem.200500282

Reference yield:

: (1R)-1-carboxy-2-(3-chloro-4-hydroxy-phenyl)-ethyl-ammonium chloride

: 866343-66-0
(S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / 1,4-dioxane; water / 0.25 h / 20 °C

1.2: 5 h / 20 °C

2.1: potassium carbonate / acetonitrile / 2 h / 80 °C

3.1: sodium hydroxide / methanol; water / 3 h / 20 °C

4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C

5.1: sodium hydroxide / methanol; water / 4 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 16 h / 20 - 35 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; morpholine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2020.112364