di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate

Base Information

• Chemical Name: di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate
• CAS No.: 1050369-77-1
• Molecular Formula: C₂₉H₄₃N₅O₇
• Molecular Weight: 573.69
• Mol file: 1050369-77-1.mol

Synonyms:di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate

Chemical Property of di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate

There total 1 articles about di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

(S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid (1050369-75-9) + L-glutamic acid di-tert-butyl ester hydrochloride (32677-01-3) → di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate (1050369-77-1)

Guidance literature:

With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm800555h

Reference yield: 91.0%

di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate (1050369-77-1) → (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioic acid (1050369-44-2)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 0 - 20 ℃;

DOI:10.1021/jm800555h

upstream raw materials:

(S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid

L-glutamic acid di-tert-butyl ester hydrochloride

Downstream raw materials:

(S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioic acid