(S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid

Base Information

• Chemical Name: (S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid
• CAS No.: 1050369-75-9
• Molecular Formula: C₁₆H₂₀N₄O₄
• Molecular Weight: 332.359
• Mol file: 1050369-75-9.mol

Synonyms:(S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid

Chemical Property of (S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid

There total 1 articles about (S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoate (1050369-74-8) → (S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid (1050369-75-9)

Guidance literature:

With lithium hydroxide monohydrate; water; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jm800555h

Reference yield: 28.0%

(S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoic acid (1050369-75-9) + L-glutamic acid di-tert-butyl ester hydrochloride (32677-01-3) → di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate (1050369-77-1)

Guidance literature:

With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/jm800555h

upstream raw materials:

methyl (S)-4-(4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzoate

Downstream raw materials:

di-tert-butyl (S)-2-(4-((S)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-methoxybutyl)benzamido)pentanedioate