[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone

Base Information

Chemical Name:[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone
CAS No.:1443118-44-2
Molecular Formula:C₂₁H₂₀FNO₃
Molecular Weight:353.393
Hs Code.:

Synonyms:[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone

Suppliers and Price of [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ML 337
10mg
$ 460.00

TRC
ML337
2.5mg
$ 220.00

Tocris
ML337 ≥98%(HPLC)
10
$ 183.00

Tocris
ML337 ≥98%(HPLC)
50
$ 753.00

ApexBio Technology
ML337
50mg
$ 1290.00

Total 5 raw suppliers

Chemical Property of [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

ML 337 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses ML 337 is a mGlu3 selective negative allosteric modulator with the ability to penetrate the central nervous system.

Technology Process of [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone

There total 3 articles about [2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1443118-42-0
2-fluoro-4-((4-methoxyphenyl)ethynyl)benzoic acid

: 198976-43-1
(R)-piperidin-3-ol hydrochloride

: 1443118-44-2
[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1021/jm400439t

Reference yield:

: 124700-40-9
2-fluoro-4-iodo-benzoic acid

: 1443118-44-2
[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 1.08 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 4 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm400439t

Reference yield:

: 768-60-5
4-methoxyphenylacetylen

: 1443118-44-2
[2-fluoro-4-[2-(4-methoxyphenyl)ethynyl]phenyl][(3R)-3-hydroxy-1-piperidinyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylamine / N,N-dimethyl-formamide / 1.08 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide / 4 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm400439t