ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate

Base Information

Chemical Name:ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate
CAS No.:142721-13-9
Molecular Formula:C₂₂H₁₈ClF₄NO₄
Molecular Weight:471.836
Hs Code.:

Synonyms:ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate

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Chemical Property of ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate

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Technology Process of ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate

There total 7 articles about ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 105-36-2
ethyl bromoacetate

: 142721-19-5
5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylideneindolin-2-one

: 142721-13-9
ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate

Guidance literature:: With potassium carbonate; In butanone; for 24h; Heating;
DOI:10.1021/jo00043a044

Reference yield:

: 123-30-8
4-amino-phenol

: 142721-13-9
ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / K₂CO₃ / acetonitrile / 25 h / Heating

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

3: 43 percent / p-toluenesulfonic acid / toluene / Heating

4: 81 percent / Raney nickel / ethanol / Ambient temperature

5: 74 percent / piperidine / Heating

6: 46 percent / K₂CO₃ / butan-2-one / 24 h / Heating

With piperidine; chlorine; nickel; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In ethanol; toluene; acetonitrile; butanone;
DOI:10.1021/jo00043a044

Reference yield:

: 77227-99-7
3,4-difluoro-5-chloro-α,α,α-trifluorotoluene

: 142721-13-9
ethyl 5-<(2-chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy>-3-isopropylidene-2-oxo-1-indolineacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / K₂CO₃ / acetonitrile / 25 h / Heating

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

3: 43 percent / p-toluenesulfonic acid / toluene / Heating

4: 81 percent / Raney nickel / ethanol / Ambient temperature

5: 74 percent / piperidine / Heating

6: 46 percent / K₂CO₃ / butan-2-one / 24 h / Heating

With piperidine; chlorine; nickel; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In ethanol; toluene; acetonitrile; butanone;
DOI:10.1021/jo00043a044