Technology Process of C18H20ClNO2
There total 4 articles about C18H20ClNO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(3-chloro-4-methoxyphenylethyl)-β-(3'-methoxyphenyl)acetamide;
With
phosphorus pentoxide; trichlorophosphate;
In
toluene;
at 0 ℃;
for 6h;
Inert atmosphere;
Reflux;
With
sodium tetrahydroborate;
In
methanol;
at -78 ℃;
for 2h;
Inert atmosphere;
Reflux;
DOI:10.1016/j.ejmech.2013.07.036
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; ammonium acetate / 4 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / Inert atmosphere; Reflux
3.1: sodium hydroxide / dichloromethane; water / 3 h / 0 - 20 °C
4.1: phosphorus pentoxide; trichlorophosphate / toluene / 6 h / 0 °C / Inert atmosphere; Reflux
4.2: 2 h / -78 °C / Inert atmosphere; Reflux
With
lithium aluminium tetrahydride; phosphorus pentoxide; ammonium acetate; acetic acid; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
3.1: |Schotten-Baumann Reaction / 4.1: |Bischler-Napieralski Reaction;
DOI:10.1016/j.ejmech.2013.07.036
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydroxide / dichloromethane; water / 3 h / 0 - 20 °C
2.1: phosphorus pentoxide; trichlorophosphate / toluene / 6 h / 0 °C / Inert atmosphere; Reflux
2.2: 2 h / -78 °C / Inert atmosphere; Reflux
With
phosphorus pentoxide; sodium hydroxide; trichlorophosphate;
In
dichloromethane; water; toluene;
1.1: |Schotten-Baumann Reaction / 2.1: |Bischler-Napieralski Reaction;
DOI:10.1016/j.ejmech.2013.07.036
