4903-09-7

Basic information

• Product Name: 3-CHLORO-4-METHOXYBENZALDEHYDE
• Synonyms: TIMTEC-BB SBB003854;AKOS B029259;3-CHLORO-4-METHOXYBENZALDEHYDE;3-CHLORO-4-METHOXYBENZENECARBALDEHYDE;3-CHLORO-P-ANISALDEHYDE;CHEMBRDG-BB 6945816;3-chloroanisaldehyde;3-CHLORO-P-ANISALDEHYDE, 98+% GC
• CAS NO: 4903-09-7
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• EINECS: 225-532-2
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Adehydes, Acetals & Ketones;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds
• Mol File: 4903-09-7.mol
• Article Data: 30

Chemical Properties

• Melting Point: 56-60 °C(lit.)
• Boiling Point: 269.1 °C at 760 mmHg
• Flash Point: 120.7 °C
• Appearance: /
• Density: 1.244 g/cm³
• Vapor Pressure: 0.00738mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-CHLORO-4-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-METHOXYBENZALDEHYDE(4903-09-7)
• EPA Substance Registry System: 3-CHLORO-4-METHOXYBENZALDEHYDE(4903-09-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 4903-09-7(Hazardous Substances Data)

Usage

General Description

3-CHLORO-4-METHOXYBENZALDEHYDE is a chemical compound with the molecular formula C8H7ClO2. It is a yellow solid that is commonly used in the synthesis of pharmaceuticals and agrochemicals. 3-CHLORO-4-METHOXYBENZALDEHYDE is known for its aromatic and aldehyde-like odor, and it is often used as a building block in the production of various organic compounds. 3-CHLORO-4-METHOXYBENZALDEHYDE is also used as an intermediate in the synthesis of dyes, perfumes, and other aromatic compounds. It is important to handle this chemical with care, as it can be harmful if ingested or inhaled, and can cause skin and respiratory irritation upon contact.

InChI:InChI=1/C8H7ClO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-5H,1H3

Upstream product

• 74-90-8 hydrogen cyanide 
• 766-51-8 2-Chloroanisole 
• 37908-96-6 3-chloro-4-methoxy benzoic acid 
• 115514-77-7 (3-chloro-4-methoxyphenyl)methanamine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 50638-47-6 4-bromo-2-chloro-1-methoxybenzene 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 2420-16-8 4-hydroxy-3-chlorobenzaldehyde 
• 77-78-1 dimethyl sulfate 
• 584-08-7 potassium carbonate 
• 74-88-4 methyl iodide 
• 3964-57-6 methyl 4-hydroxy-3-chlorobenzoate 
• 3964-58-7 3-chloro-4-hydroxybenzoic acid 

Downstream Products

• 58236-76-3 3-chloro-4-methoxycinnamic acid 
• 861207-97-8 4-(3-chloro-4-methoxy-benzylidene)-2-phenyl-4H-oxazol-5-one 
• 212576-67-5 N-(3-chloro-4-methoxybenzyl)formamide 
• 1224713-61-4 2-chloro-[4-(E)-2-(3,5-dimethoxyphenyl)ethen-1-yl]-1-methoxybenzene 
• 1369423-49-3 3-chloro-4-methoxybenzyl diphenyl phosphate 
• 1369423-45-9 (R)-4-(3-chloro-4-methoxybenzyl)-4-methyl-2-phenyloxazol-5(4H)-one 
• 52516-53-7 2-(3-chloro-4-methoxyphenyl)ethanol 

Relevant articles and documents

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Activator free, expeditious and eco-friendly chlorination of activated arenes by N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI)

N-Chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI) has been explored for the first time as a chlorinating reagent for direct chlorination of various activated arenes and heterocycles without any activator. A comparative in-silico study was performed to determine the electrophilic character for NCBSI and commercially available N-chloro reagents to reveal the reactivity on a theoretical viewpoint. The reagent was prepared by an improved method avoiding the use of hazardous t-butyl hypochlorite. This reagent was proved to be very reactive compared to other N-chloro reagents. The precursor of the reagent N-(phenylsulfonyl)benzene sulfonamide was recovered from aqueous spent, which can be recycled to synthesize NCBSI. The eco-friendly protocol was equally applicable for the synthesis of industrially important chloroxylenol as an antibacterial agent.

Amplification of Trichloroisocyanuric Acid (TCCA) Reactivity for Chlorination of Arenes and Heteroarenes via Catalytic Organic Dye Activation

Heteroarenes and arenes that contain electron-withdrawing groups are chlorinated in good to excellent yields (scalable to gram scale) using trichloroisocyanuric acid (TCCA) and catalytic Brilliant Green (BG). Visible-light activation of BG serves to amplify the electrophilic nature of TCCA, providing a mild alternative approach to acid-promoted chlorination of deactivated (hetero)aromatic substrates. The utility of the TCCA/BG system is demonstrated through comparison to other chlorinating reagents and by the chlorination of pharmaceuticals including caffeine, lidocaine, and phenazone.