2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

Base Information

Chemical Name:2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide
CAS No.:1370447-37-2
Molecular Formula:C₂₁H₂₃ClN₄O₃
Molecular Weight:414.892
Hs Code.:

Synonyms:2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

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Chemical Property of 2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

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Technology Process of 2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

There total 6 articles about 2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370447-26-9
2-[3-(3-chlorophenyl)-1-(4-ethenylphenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

: 1370447-37-2
2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

Guidance literature:: 2-[3-(3-chlorophenyl)-1-(4-ethenylphenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide; With borane-THF; In tetrahydrofuran; for 1h; Inert atmosphere; Cooling with ice;

With sodium peroxoborate tetrahydrate; In tetrahydrofuran; water; at 20 ℃;

Reference yield:

: 62123-73-3
ethyl 2‐(3‐chlorophenyl)‐2‐oxoacetate

: 1370447-37-2
2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / methanol; tetrahydrofuran / 20 °C / Cooling with ice

2.1: hydrogenchloride / water / 72 h

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 8 h / Inert atmosphere; Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 5 h / 100 °C / Inert atmosphere

6.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

6.2: 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; diphenyl phosphoryl azide; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1370447-13-4
2-[1-(4-bromophenyl)-3-(3-chlorophenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

: 1370447-37-2
2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 5 h / 100 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

2.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; In tetrahydrofuran; toluene;