2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

Base Information

Chemical Name:2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide
CAS No.:1370444-27-1
Molecular Formula:C₂₆H₃₀ClN₅O₃
Molecular Weight:496.009
Hs Code.:

Synonyms:2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

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Chemical Property of 2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

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Technology Process of 2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

There total 8 articles about 2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1159599-99-1,1045709-32-7,1254966-66-9
2-oxa-6-azaspiro[3.3]heptan-6-ium carboxyformate

: 1370447-63-4
2-{3-(3-chlorophenyl)-5-oxo-1-[4-(2-oxoethyl)phenyl]-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

: 1370444-27-1
2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In chloroform; at 20 ℃; for 72h;

Reference yield:

: 1370447-13-4
2-[1-(4-bromophenyl)-3-(3-chlorophenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

: 1370444-27-1
2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 5 h / 100 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

2.2: 20 °C

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / chloroform / 72 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; sodium tris(acetoxy)borohydride; acetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; chloroform; dimethyl sulfoxide; toluene;

Reference yield:

: 1370447-37-2
2-{3-(3-chlorophenyl)-1-[4-(2-hydroxyethyl)phenyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-N-(propan-2-yl)acetamide

: 1370444-27-1
2-[3-(3-chlorophenyl)-1-{4-[2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]phenyl}-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]-N-(propan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / chloroform / 72 h / 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In chloroform; dimethyl sulfoxide;