(R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide

Base Information

• Chemical Name: (R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide
• CAS No.: 1621272-04-5
• Molecular Formula: C₂₇H₂₃F₃N₄O₅S
• Molecular Weight: 572.565

Synonyms:(R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide

Chemical Property of (R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide

Chemical Property:

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Technology Process of (R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide

There total 14 articles about (R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-4-yl)benzonitrile (1621269-90-6) + 4-aminotetrahydro-2H-thiopyran-1,1-dioxide (210240-20-3) + 4-Nitrophenyl chloroformate (7693-46-1) → (R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide (1621272-04-5)

Guidance literature:

(R)-4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-4-yl)benzonitrile; 4-Nitrophenyl chloroformate; With dmap; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

4-aminotetrahydro-2H-thiopyran-1,1-dioxide; In acetonitrile; for 1h;

Reference yield:

C28H17F3N4O6 (1621273-35-5) + 4-aminotetrahydro-2H-thiopyran-1,1-dioxide (210240-20-3) → (R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide (1621272-04-5)

Guidance literature:

In acetonitrile; for 1h;

Reference yield:

3-[[3-(trifluoromethyl)phenyl]amino]-2-cyclopenten-1-one → (R)-4-(4-cyanophenyl)-2,5-dioxo-N-(1,1-dioxo-hexahydro-1λ6-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidine-3(2H)-carboxamide (1621272-04-5)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane / 20 °C / Reflux

2: carbon dioxide; diethylamine / methanol / 40 °C / 75007.5 Torr

3: N-ethyl-N,N-diisopropylamine; dmap / acetonitrile / 20 °C

4: acetonitrile / 1 h

With dmap; carbon dioxide; diethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;

upstream raw materials:

C₂₈H₁₇F₃N₄O₆

4-aminotetrahydro-2H-thiopyran-1,1-dioxide

(R)-4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-4-yl)benzonitrile

diethyl (4-cyanophenyl)methylenedicarbamate

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