Thalicarpine

Base Information

Chemical Name:Thalicarpine
CAS No.:5373-42-2
Molecular Formula:C₄₁H₄₈N₂O₈
Molecular Weight:696.841
Hs Code.:
NSC Number:68075
UNII:8X1D791RF6
DSSTox Substance ID:DTXSID90202011
Nikkaji Number:J7.977D
Wikidata:Q27108417
NCI Thesaurus Code:C869
Metabolomics Workbench ID:53478
ChEMBL ID:CHEMBL507100
Mol file:5373-42-2.mol

Synonyms:Thaliblastine;thalicarpine

Suppliers and Price of Thalicarpine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
THALICARPINE 95.00%
5MG
$ 498.49

Total 9 raw suppliers

Chemical Property of Thalicarpine

Chemical Property:

Vapor Pressure:3.91E-23mmHg at 25°C
Melting Point:160-161°
Refractive Index:1.4670 (estimate)
Boiling Point:762.2°Cat760mmHg
Flash Point:181.4°C
PSA：80.32000
Density:1.194g/cm³
LogP:6.93870
XLogP3:6.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:11
Exact Mass:696.34106649
Heavy Atom Count:51
Complexity:1120

Purity/Quality:

99% ^*data from raw suppliers

THALICARPINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC5=CC(=C(C=C5CC6C7=CC(=C(C=C7CCN6C)OC)OC)OC)OC)OC)OC
Isomeric SMILES:CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC(=C(C=C43)OC)OC5=CC(=C(C=C5C[C@H]6C7=CC(=C(C=C7CCN6C)OC)OC)OC)OC)OC)OC
Description A complex alkaloid, thaliblastine occurs in Thalictrum minus elatum and has been assigned the structure given on the basis of chemical and spectroscopic investigations. The alkaloid has marked antitumour activity but rapid administration of the base causes brachycardia, hypotension and inhibition of respiration in laboratory animals. Slow intravenous injection, however, produces none of these effects. Thaliblastine is cytotoxic to HEF and Sa9 cells in vitro.

Technology Process of Thalicarpine

There total 4 articles about Thalicarpine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₄₇H₅₆N₂O₁₂

: 74-88-4
methyl iodide

: 4829-32-7,16624-97-8,35721-25-6,5373-42-2
Thalicarpine

Guidance literature:: C₄₇H₅₆N₂O₁₂; methyl iodide; With caesium carbonate; In dimethyl sulfoxide;

With lithium aluminium tetrahydride; In tetrahydrofuran; for 12h; Reflux;
DOI:10.1021/acscatal.8b04443