3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

Base Information

Chemical Name:3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester
CAS No.:857530-87-1
Molecular Formula:C₁₈H₁₅BrClNO₂
Molecular Weight:392.68
Hs Code.:

Synonyms:3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

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Chemical Property of 3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

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Technology Process of 3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

There total 2 articles about 3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 42205-33-4
(E)-ethyl 3-(4-bromophenyl)-2-cyanoacrylate

: 873-77-8
(4-chlorphenyl)magnesium bromide

: 857530-87-1
3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

Guidance literature:: In tetrahydrofuran; toluene; at 0 - 85 ℃; for 3h;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 857530-87-1
3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine / toluene / 1 h / Heating / reflux

2.1: tetrahydrofuran; toluene / 3 h / 85 °C

2.2: 0 °C

With piperidine; In tetrahydrofuran; toluene; 2.1: Grignard Reaction;

Reference yield:

: 857530-87-1
3-(4-bromo-phenyl)-3-(4-chloro-phenyl)-2-cyano-propionic acid ethyl ester

: C₁₉H₁₈BrNS

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; water; acetic acid / 2 h / Heating / reflux

2.1: benzotriazol-1-ol / dichloromethane / 0.25 h

2.2: 16 h

3.1: aluminum (III) chloride; lithium aluminium tetrahydride / diethyl ether / 16 h / 0 °C

4.1: potassium carbonate / bis[tris( 1,1-dimethylethyl)phosphine]-palladium / ethanol; water; toluene / 0.5 h / 135 °C / microwave irradiation

With aluminum (III) chloride; lithium aluminium tetrahydride; sulfuric acid; water; potassium carbonate; benzotriazol-1-ol; acetic acid; bis[tris( 1,1-dimethylethyl)phosphine]-palladium; In diethyl ether; ethanol; dichloromethane; water; toluene; 4.1: Suzuki Coupling;