4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid

Base Information

Chemical Name:4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid
CAS No.:1268621-42-6
Molecular Formula:C₂₄H₁₉FN₄O₄
Molecular Weight:446.438
Hs Code.:

Synonyms:4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid

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Chemical Property of 4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid

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Technology Process of 4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid

There total 6 articles about 4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268621-47-1
1-tert-butyl 2-methyl 4-[4-(4-aminophenoxy)pyridin-2-yl]-1H-pyrrole-1,2-dicarboxylate

: 1268621-42-6
4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.5 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

3: sodium hydroxide / methanol; water; tetrahydrofuran / 2 h / 70 °C

With trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 630125-70-1
4-((2-chloropyridin-4-yl)oxy)aniline

: 1268621-42-6
4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,4-dioxane / 0.5 h / 70 °C / Inert atmosphere

2: tetrahydrofuran / 0.5 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

4: sodium hydroxide / methanol; water; tetrahydrofuran / 2 h / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: C₂₈H₂₇FN₄O₄

: 1268621-42-6
4-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C

2.2: pH 4

With trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;