2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester

Base Information

• Chemical Name: 2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester
• CAS No.: 915222-58-1
• Molecular Formula: C₁₈H₂₃NO₅
• Molecular Weight: 333.384
• Mol file: 915222-58-1.mol

Synonyms:2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester

Chemical Property of 2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester

There total 1 articles about 2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-proline methyl ester monohydrochloride (2133-40-6) → 2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester (915222-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 79 percent / sodium hydrogen carbonate / benzene / 20 °C

2.1: diethylzinc / CH₂Cl₂; hexane / 0.17 h / 0 °C

2.2: 70 percent / CH₂Cl₂; hexane

With diethylzinc; sodium hydrogencarbonate; In hexane; dichloromethane; benzene;

DOI:10.1021/jo061184o

Reference yield: 74.0%

2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester (915222-58-1) + carbon disulfide (75-15-0,12122-00-8) + methyl iodide (74-88-4) → (S)-1-[(S)-2-((S)-Methylsulfanylthiocarboxyoxy-phenyl-methyl)-4-oxo-pentanoyl]-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:

2-(5-hydroxy-5-methyl-2-phenyltetrahydrofuran-3-carbonyl)cyclopentanecarboxylic acid methyl ester; carbon disulfide; With sodium hydride; In tetrahydrofuran; at 0 ℃;

methyl iodide; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jo061184o

upstream raw materials:

L-proline methyl ester monohydrochloride