[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

Base Information

Chemical Name:[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
CAS No.:512809-60-8
Molecular Formula:C₇H₆F₄N₂O₂
Molecular Weight:226.13
Hs Code.:
DSSTox Substance ID:DTXSID901235198
Mol file:512809-60-8.mol

Synonyms:512809-60-8;[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid;2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetic acid;2-[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid;2-(3,5-bis(difluoromethyl)-1H-pyrazol-1-yl)acetic acid;MFCD03419711;(3,5-bis-difluoromethyl-pyrazol-1-yl)-acetic acid;3,5-Bis(difluoromethylpyrazol-1-yl)acetic acid;SCHEMBL30579;AK-968/41170093;1H-pyrazole-1-acetic acid, 3,5-bis(difluoromethyl)-;C7H6F4N2O2;DTXSID901235198;BBL038279;STK301631;AKOS000308219;FS-6362;CS-0217747;EN300-83601;(3,5-Bisdifluoromethylpyrazol-1-yl)acetic acid;A924382;3,5-Bis(difluoromethyl)-1H-pyrazole-1-acetic acid;[3,5-bis-(difluoromethyl)-1H-pyrazol-1-yl]acetic acid;2-(3,5-bis(difluoromethyl)-1H-pyrazol-1-yl)aceticacid;(3,5-bis-difluoromethyl-pyrazol-1-yl)-acetic acid, AldrichCPR

Suppliers and Price of [3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
5g
$ 1500.00

Matrix Scientific
[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
1g
$ 500.00

Matrix Scientific
[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
0.500g
$ 400.00

Crysdot
2-(3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl)aceticacid 95+%
1g
$ 395.00

Chemenu
2-(3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl)aceticacid 95%
1g
$ 373.00

Biosynth Carbosynth
[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
100 mg
$ 100.00

Biosynth Carbosynth
[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
50 mg
$ 60.00

Biosynth Carbosynth
[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
500 mg
$ 300.00

Biosynth Carbosynth
[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
250 mg
$ 200.00

Biosynth Carbosynth
[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid
1 g
$ 480.00

Total 5 raw suppliers

Chemical Property of [3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:226.03654009
Heavy Atom Count:15
Complexity:239

Purity/Quality:

97% ^*data from raw suppliers

[3,5-Bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=C(N(N=C1C(F)F)CC(=O)O)C(F)F

Technology Process of [3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

There total 2 articles about [3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1006482-19-4
ethyl 2-(3,5-bis(difluoromethyl)-1H-pyrazol-1-yl)acetate

: 512809-60-8
[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 0 - 27 ℃; for 16h; Inert atmosphere;

Reference yield:

: 70086-62-3
1,1,5,5-tetrafluoropentane-2,4-dione

: 512809-60-8
[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / ethanol / 3 h / 26 - 100 °C / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran; methanol / 16 h / 0 - 27 °C / Inert atmosphere

With sulfuric acid; water; lithium hydroxide; In tetrahydrofuran; methanol; ethanol;

Reference yield: 76.0%

: 512809-60-8
[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]acetic acid

: (S)-N-((6P)-7-(2-(1-amino-2-(3,5-difluorophenyl)ethyl)-7-bromo-4-oxoquinazolin-3 (4H)-yl)-4-chloro-1-(2,2-difluoroethyl)-1H-indazol-3-yl)cyclopropanesulfonamide

: (S)-2-(3,5-bis(difluoromethyl)-1H-pyrazol-1-yl)-N-(1-(7-bromo-(3P)-3-(4-chloro-3-(cyclopropanesulfonamido)-1-(2,2-difluoroethyl)-1H-indazol-7-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(3,5-difluorophenyl)ethyl)acetamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 27 ℃; Inert atmosphere;